Changes of blood serum cytokine profile in the patients with papillomavirus infection before and after therapeutic pregravid preparation

Human papillomavirus is one of the most common sexually transmitted viruses. The state immune system fundamental to outcome infectious processes viral and bacterial genesis, thus determining quality pre-gravidar preparation. purpose present study was perform a comprehensive analysis pro- anti-inflammatory cytokines in infection provide immunological assessment therapeutic efficiency women. Materials methods: 137 patients with were observed, at average age 312.5 years old. consisted 2 stages: stage 1 included humoral innate immunity women main group, distributed according etiological factor, i.e., G-I (PVI); G-II presented herpetic (PVI + HVI 1/2 type); G-III Chlamydia Trash.). At Stage 2, we performed for PVI: G-IA group (PVI) used Inosine pranobex (n = 11); IB Solanum tuberosum applied 10); A herpes (PVI+HVI type), Valacyclovir 24); G-IIB administered 23); G-IIIA chlamydia Trash.) Doxycycline 20); from IIIB treated 19). Determination levels IL-17A, IL-12 p70, p40, IL- 13 blood serum carried out using specific reagents RD Diagnostics Inc. (USA). Results: Before therapy, an increase IL-17 IL-13 (p 0.05), pronounced deficiency p40 p70 0.001) observed patients. After course decrease p 70 found. level remained without dynamic changes. approaches had positive effect all studied groups patients, regardless drug administered.